Submitted by Diane Hoffman on Sun, 09/13/2015

Alzheimer’s disease could be controlled with Resveratrol supplements: Research

A new research has indicated that a biomarker for Alzheimer’s disease can be impacted by intake of Resveratrol, a compound found in dark chocolate, red grapes and red wine. As Resveratrol can stabilize amyloid-beta40 levels in the blood and cerebrospinal fluid, it can reduce the formation of plaque in the brain.

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Resveratrol is a compound found in abundance in red grapes, dark chocolate and red wine. It has been earlier credited for offering many health benefits and this is the reason, health studies conducted in the past have suggested eating dark chocolate and drinking moderate amount of red wine as a healthy option. A study conducted by medical researchers at Georgetown University has found that Resveratrol also affects an Alzheimer’s disease biomarker.

The research team found that amyloid-beta40 levels in the blood and cerebrospinal fluid remained stable among individuals who were given Resveratrol in their diet. For control group which was not given Resveratrol, the level of amyloid-beta40 witnessed a decline.

The research team conducted a double-blind, placebo controlled study. The study group included 119 participants, all with mild-to-moderate Alzheimer’s. The group given Resveratrol had mean age of 70 years while the placebo group had mean age of 73 years.

Amyloid-beta levels in Alzheimer’s patients decrease in the cerebrospinal fluid and deposit in the brain. These deposits become insoluble and lead to plaque formation, considered as a major reason for debilitating condition. The insoluble plaque ultimately leads to death of the nerve cells in the brain.

The research team added that additional studies will be needed before they could recommend people to increase their intake of dark chocolate and red wine.

The study has been published in Friday edition of the journal Neurology. The research team suggests that Resveratrol activates proteins called sirtuins. These proteins are also activated by calorie restriction, and may have anti-aging effects.

“It’s showing us a new mechanism, or a new pathway, towards Alzheimer’s treatments,” lead researcher Dr. R. Scott Turner, director of the Memory Disorders Program at Georgetown University Medical Center in Washington, D.C. said. “This is targeting amyloid in an indirect way,” Dr. Turner said.

The research team indicated that the Resveratrol given to the study subjects was equivalent of Resveratrol found in 10,000 bottles of red wine. This indicates that there will be a little positive impact of drinking red wine but as little as 50mg of pure red grape Resveratrol in supplement form would have the same effect and be a practical method of taking the required amount.

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